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POF shows an inclination to have exons.

Splicing is normally considered to be a procedure that happen once transcription. But not, cotranscriptional splicing was visualized for the Drosophila more 25 years ago (51). Newer research has showed that cotranscriptional splicing is more common than just used to be believed (52) and have you to splicing may start since the a good cotranscriptional feel and you may remain posttranscriptionally (six, 50). Therefore, the solid exon bias stated here is compatible with POF binding to nascent RNAs. Cotranscriptional splicing is assumed so you’re able to trust collaboration anywhere between exon identification and also the speed away from transcription by RNP2. Due to the fact POF are linked to nascent RNAs, this losing the rate out of transcription over exons create define the exon prejudice seen at the chromatin peak inside the Processor chip-chip experiments (27).